The best cure for infertility
Fertomide is an antiestrogenic drug of non-steroidal structure. Stimulates ovulation. It is expected that clomiphene blocks estrogen receptors in the hypothalamus and ovaries and increases the secretion of gonadotropic hormones, including luteinizing hormone, by means of feedback. This, in turn, stimulates maturation and endocrine activity of the follicle in the ovary, increases the concentration of estradiol in the blood. At low levels of estrogen hormones in the body shows moderate estrogenic effect. At high levels of estrogen shows antiestrogenic effect, slows down the secretion of gonadotropins in high doses. Does not exhibit progestagenic and androgenic activity. Ovulation stimulation in women with infertility due to secondary ovarian pituitary function, mainly due to functional hypothalamic-pituitary disorders. Ovulation induction in women with anovulatory cycle. Anovulatory disorders of central hypothalamic origin, secondary amenorrhoea of different etiology, oligomenorrhoea.
Features of use.
Before prescribing the drug, patients are examined to exclude malignant tumors of the uterus or breast, cysts or ovarian enlargement (Stein-Leventhal syndrome is not contraindicated before prescribing the drug), as well as other diseases in which the use of clomiphene is contraindicated. In case of disorders of oocyte maturation, other causes of infertility should be excluded or their average therapy should be carried out before clomiphene is prescribed. It is recommended that liver and kidney function tests be performed prior to treatment. It is advisable to prescribe the drug in cases where the total content of gonadotropins in the urine is slightly lower than normal or within normal limits, ovaries palpatorno without changes, the functions of the thyroid gland and adrenal glands are normal. It should be taken into account that the drug is more effective with sufficient levels of endogenous estrogen, less effective with low levels of estrogen and almost ineffective with low levels of gonadotropic hormones of the pituitary gland.
Before prescribing the drug it is always necessary to conduct a thorough gynecological examination. Fertomide is used only with constant gynecological control! In the course of treatment the necessary regular control of the ovaries. Gynecological examination to exclude abnormal ovarian enlargement is carried out before each next course of treatment with the drug. Patients should be warned about the need to immediately inform the doctor about the occurrence of abdominal pain, as well as the increase in body weight. In case of abdominal pain during the period of the drug administration, a thorough examination of the patient is carried out. If during the treatment period the ovarian enlargement is determined, as well as cystic degeneration, the use of the drug should be discontinued until the normalization of ovarian size. After that, the total dose or duration of therapy should be reduced.
During Fertomidomide treatment, the basal temperature should be regularly monitored and in case of biphasic use of the drug should be stopped. Treatment is carried out with the use of minimum effective doses of the drug. It is not recommended to conduct more than 6 courses. In the course of treatment, careful monitoring of the patient's condition is carried out, closely monitoring the signs of pregnancy. It should be noted that pregnancy often occurs during the cycle, which begins after the drug is withdrawn.
After clomiphene therapy to determine the timing of ovulation is difficult, there is often a lack of yellow body, so after conception is recommended to prescribe progesterone prophylactically.
Due to the fact that clomiphene may cause drowsiness and circulating visual disturbances, during treatment it is necessary to refrain from working with motor vehicles and mechanisms.
After successful treatment with the drug the frequency of multiple pregnancies increases.
During the use of the drug for the treatment of men the necessary regular control of spermogram.